细菌
生物
乳酸
核苷酸
嘌呤代谢
嘌呤
嘧啶代谢
新陈代谢
微生物代谢
代谢途径
代谢组
代谢组学
生物化学
遗传学
基因
酶
生物信息学
代谢物
作者
Mogens Kilstrup,Karin Hammer,Peter Ruhdal Jensen,Jan Martinussen
出处
期刊:Fems Microbiology Reviews
[Oxford University Press]
日期:2005-08-01
卷期号:29 (3): 555-590
被引量:226
标识
DOI:10.1016/j.fmrre.2005.04.006
摘要
Most metabolic reactions are connected through either their utilization of nucleotides or their utilization of nucleotides or their regulation by these metabolites. In this review the biosynthetic pathways for pyrimidine and purine metabolism in lactic acid bacteria are described including the interconversion pathways, the formation of deoxyribonucleotides and the salvage pathways for use of exogenous precursors. The data for the enzymatic and the genetic regulation of these pathways are reviewed, as well as the gene organizations in different lactic acid bacteria. Mutant phenotypes and methods for manipulation of nucleotide pools are also discussed. Our aim is to provide an overview of the physiology and genetics of nucleotide metabolism and its regulation that will facilitate the interpretation of data arising from genetics, metabolomics, proteomics, and transcriptomics in lactic acid bacteria.
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