烷基
芳基
亲核细胞
催化作用
化学
卤素
激进的
催化循环
光催化
组合化学
光化学
有机化学
光催化
作者
Lewis Caiger,Huaibo Zhao,Timothée Constantin,James J. Douglas,Daniele Leonori
标识
DOI:10.1021/acscatal.3c00571
摘要
Here, we report a toolbox strategy to cross-couple unactivated secondary alkyl iodides with various N-, O-, and C-based nucleophiles. This strategy harnesses the ability of photoredox-generated phenyl radicals to mediate halogen-atom transfer (XAT) and convert alkyl iodides into the corresponding radicals. These species engage in a second catalytic cycle, mediated by copper, which enables C–N/O/C bond formation with the various nucleophiles.
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