3D打印
自愈水凝胶
材料科学
墨水池
纳米技术
挤压
计算机科学
复合材料
高分子化学
作者
Elena Munoz-Perez,Arantza Perez‐Valle,Manoli Igartua,Edorta Santos‐Vizcaíno,Rosa Marı́a Hernández
出处
期刊:Biomaterials advances
日期:2023-06-01
卷期号:149: 213414-213414
被引量:11
标识
DOI:10.1016/j.bioadv.2023.213414
摘要
The formulation of hydrogels that meet the necessary flow characteristics for their extrusion-based 3D printing while providing good printability, resolution, accuracy and stability, requires long development processes. This work presents the technological development of a hydrogel-based ink of Laponite and alginate and evaluates its printing capacity. As a novelty, this article reports a standardizable protocol to quantitatively define the best printing parameters for the development of novel inks, providing new printability evaluation parameters such as the Printing Accuracy Escalation Index. As a result, this research develops a printable Laponite-Alginate hydrogel that presents printability characteristics. This ink is employed for the reproducible manufacture of 3D printed scaffolds with versatile and complex straight or curved printing patterns for a better adaptation to different final applications. Obtained constructs prove to be stable over time thanks to the optimization of a curing process. In addition, the study of the swelling and degradation behavior of the Laponite and alginate 3D printed scaffolds in different culture media allows the prediction of their behavior in future in vitro or in vivo developments. Finally, this study demonstrates the absence of cytotoxicity of the printed formulations, hence, setting the stage for their use in the field of biomedicine.
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