口腔1
癌症研究
转移
血管生成
医学
癌症
电压依赖性钙通道
药理学
钙
内科学
作者
Olivier Mignen,Jean‐Pierre Vannier,Pascale Schneider,Yves Renaudineau,Souleymane Abdoul-Azize
标识
DOI:10.1016/j.bcp.2023.115955
摘要
In non-excitable cells, Orai proteins represent the main channel for Store-Operated Calcium Entry (SOCE), and also mediate various store-independent Calcium Entry (SICE) pathways. Deregulation of these pathways contribute to increased tumor cell proliferation, migration, metastasis, and angiogenesis. Among Orais, Orai1 is an attractive therapeutic target explaining the development of specific modulators. Therapeutic trials using Orai1 channel inhibitors have been evaluated for treating diverse diseases such as psoriasis and acute pancreatitis, and emerging data suggest that Orai1 channel modulators may be beneficial for cancer treatment. This review discusses herein the importance of Orai1 channel modulators as potential therapeutic tools and the added value of these modulators for treating cancer.
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