Forsythiaside A attenuates mastitis via PINK1/Parkin-mediated mitophagy

粒体自噬 帕金 品脱1 乳腺炎 炎症 免疫学 生物 药理学 化学 医学 细胞凋亡 自噬 微生物学 疾病 帕金森病 内科学 生物化学
作者
Jingjing Liu,Yingkui Gao,Huaqiang Zhang,Zhonghua Hao,Guangwei Zhou,Haojie Wen,Qing Su,Chao Tong,Yang Xu,Xuebing Wang
出处
期刊:Phytomedicine [Elsevier]
卷期号:125: 155358-155358 被引量:3
标识
DOI:10.1016/j.phymed.2024.155358
摘要

Bovine mastitis is the most common animal production disease in the global dairy industry, which affects the health of dairy cows. When bovine mastitis occurs, the mitochondrial metabolism of breast tissue increases, and the relationship between inflammation and mitophagy has become a hot topic for many scholars. The abuse of antibiotics leads to the increase of resistance to bovine mastitis. FTA is one of the main effective components of Forsythia suspensa, which has anti-inflammatory, anti-infection, anti-oxidation and anti-virus pharmacological effects, and has broad application prospects in the prevention and treatment of bovine mastitis. However, the relationship between the anti-inflammatory effects of FTA and mitophagy is still unclear. This study mainly explores the anti-inflammatory effect of FTA in bovine mastitis and the relationship between mitophagy. MAC-T cells and wild-type mice were used to simulate the in vitro and in vivo response of mastitis. After the pretreatment with FTA, CsA inhibitors and siPINK1 were used to interfere with mitophagy, and the mitochondrial function impairment and the expression of inflammatory factors were detected. It was found that pre-treatment with FTA significantly reduced LPS induced inflammatory response and mitochondrial damage, while promoting the expression of mitophagy related factors. However, after inhibiting mitophagy, the anti-inflammatory effect of FTA was inhibited. This study is the first to suggest the relationship between the anti-inflammatory effect of FTA and mitophagy. PINK1/Parkin-mediated mitophagy is one of the ways that FTA protects MAC-T cells from LPS-induced inflammatory damage.
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