cRARα: Derailleur nuclear retinoic acid chain to TCR

AllergyEarly View NEWS AND VIEWS cRARα: Derailleur nuclear retinoic acid chain to TCR Xingjie Li, Xingjie Li Inflammation and Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, China The School of Basic Medical Sciences, Southwest Medical University, Luzhou, ChinaSearch for more papers by this authorJinzhuo Tan, Jinzhuo Tan Inflammation and Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, China The School of Basic Medical Sciences, Southwest Medical University, Luzhou, ChinaSearch for more papers by this authorZongde Zhang, Corresponding Author Zongde Zhang [email protected] Inflammation and Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, China The School of Basic Medical Sciences, Southwest Medical University, Luzhou, China Correspondence Zongde Zhang, Inflammation and Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, China. Email: [email protected]Search for more papers by this author Xingjie Li, Xingjie Li Inflammation and Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, China The School of Basic Medical Sciences, Southwest Medical University, Luzhou, ChinaSearch for more papers by this authorJinzhuo Tan, Jinzhuo Tan Inflammation and Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, China The School of Basic Medical Sciences, Southwest Medical University, Luzhou, ChinaSearch for more papers by this authorZongde Zhang, Corresponding Author Zongde Zhang [email protected] Inflammation and Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, China The School of Basic Medical Sciences, Southwest Medical University, Luzhou, China Correspondence Zongde Zhang, Inflammation and Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, China. Email: [email protected]Search for more papers by this author First published: 19 January 2024 https://doi.org/10.1111/all.16034 Xingjie Li and Jinzhuo Tan contributed equally. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. CONFLICT OF INTEREST STATEMENT The authors declare that they have no conflict of interest. REFERENCES 1Zhang Z, Li J, Zheng W, et al. Peripheral lymphoid volume expansion and maintenance are controlled by gut microbiota via RALDH+ dendritic cells. Immunity. 2016; 44: 330-342. 10.1016/j.immuni.2016.01.004 CASPubMedWeb of Science®Google Scholar 2Wu R, Yuan X, Li X, et al. The bile acid-activated retinoic acid response in dendritic cells is involved in food allergen sensitization. Allergy. 2022; 77: 483-498. 10.1111/all.15039 CASPubMedWeb of Science®Google Scholar 3Hall JA, Cannons JL, Grainger JR, et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity. 2011; 34: 435-447. 10.1016/j.immuni.2011.03.003 CASPubMedWeb of Science®Google Scholar 4Gaud G, Lesourne R, Love PE. Regulatory mechanisms in T cell receptor signalling. Nat Rev Immunol. 2018; 18: 485-497. 10.1038/s41577-018-0020-8 CASPubMedWeb of Science®Google Scholar 5Brown CC, Esterhazy D, Sarde A, et al. Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program. Immunity. 2015; 42: 499-511. 10.1016/j.immuni.2015.02.003 CASPubMedWeb of Science®Google Scholar 6Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007; 204: 1757-1764. 10.1084/jem.20070590 CASPubMedWeb of Science®Google Scholar 7DePaolo RW, Abadie V, Tang F, et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011; 471: 220-224. 10.1038/nature09849 CASPubMedWeb of Science®Google Scholar 8Larange A, Takazawa I, Kakugawa K, et al. A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor alpha determines T cell activation and function. Immunity. 2023; 56: 2054-2069.e10. 10.1016/j.immuni.2023.07.017 CASPubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation