酮体
骨骼肌
心脏病
医学
血糖性
内分泌学
内科学
氧化应激
心功能曲线
疾病
糖尿病
新陈代谢
心力衰竭
作者
Shubham Soni,Seyed Amirhossein Tabatabaei Dakhili,John R. Ussher,Jason R.B. Dyck
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2024-01-09
卷期号:326 (2): C551-C566
被引量:4
标识
DOI:10.1152/ajpcell.00501.2023
摘要
β-Hydroxybutyrate (βOHB) is the major ketone in the body, and it is recognized as a metabolic energy source and an important signaling molecule. While ketone oxidation is essential in the brain during prolonged fasting/starvation, other organs such as skeletal muscle and the heart also use ketones as metabolic substrates. Additionally, βOHB-mediated molecular signaling events occur in heart and skeletal muscle cells, and via metabolism and/or signaling, ketones may contribute to optimal skeletal muscle health and cardiac function. Of importance, when the use of ketones for ATP production and/or as signaling molecules becomes disturbed in the presence of underlying obesity, type 2 diabetes, and/or cardiovascular diseases, these changes may contribute to cardiometabolic disease. As a result of these disturbances in cardiometabolic disease, multiple approaches have been used to elevate circulating ketones with the goal of optimizing either ketone metabolism or ketone-mediated signaling. These approaches have produced significant improvements in heart and skeletal muscle during cardiometabolic disease with a wide range of benefits that include improved metabolism, weight loss, better glycemic control, improved cardiac and vascular function, as well as reduced inflammation and oxidative stress. Herein, we present the evidence that indicates that ketone therapy could be used as an approach to help treat cardiometabolic diseases by targeting cardiac and skeletal muscles.
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