铑
对映选择合成
化学
催化作用
组合化学
有机化学
作者
Zexian Li,Wei Xu,Shuaishuai Song,Minyan Wang,Yue Zhao,Zhuangzhi Shi
标识
DOI:10.1002/ange.202316035
摘要
Abstract Atropisomeric phosphines hold considerable significance in asymmetric catalysis, yet their synthesis presents a formidable challenge owing to intricate multistep procedures. In this context, a groundbreaking methodology has been presented for their preparation. This innovative approach entails an atroposelective rhodium‐catalyzed C−H activation employing aryl and heteroaryl halides, chelated by a P(III) center. The essence of this strategy lies in its ability to directly construct chiral phosphine ligands in a single step, thereby exhibiting exceptional efficiency in terms of atom and redox economy. Illustrative examples serve to demonstrate the immense potential of in situ‐formed ligands in asymmetric catalysis. Mechanistic experiments have further provided invaluable insights into this transformation.
科研通智能强力驱动
Strongly Powered by AbleSci AI