大肠杆菌
结肠炎
炎症性肠病
粘附
番茄红素
化学
微生物学
药理学
生物化学
医学
生物
免疫学
内科学
抗氧化剂
疾病
基因
有机化学
作者
Yunshuang Yue,Mengxuan Shi,Xunyu Song,Chen Ma,Daotong Li,Xiao Hu,Fang Chen
标识
DOI:10.1021/acs.jafc.3c09717
摘要
Adherent-invasive Escherichia coli plays an important role in the pathogenesis of inflammatory bowel disease. Blocking the adhesion of E. coli to intestinal epithelial cells appears to be useful for attenuating inflammatory bowel disease. Lycopene has been reported to have anti-inflammatory and antimicrobial activities. The aim of this study was to test the intervention effect of lycopene on colitis in mice and to investigate the possible mechanism through which lycopene affects the adhesion of E. coli to intestinal epithelial cells. Lycopene (12 mg/kg BW) attenuated dextran sulfate sodium (DSS)-induced colitis, decreased the proportion of E. coli, and activated the NLR family pyrin domain containing 12 and inactivated nuclear factor kappa B pathways. Furthermore, lycopene inhibited the adhesion of E. coli O157:H7 to Caco-2 cells by blocking the interaction between E. coli O157:H7 and integrin β1. Lycopene ameliorated DSS-induced colitis by improving epithelial barrier functions and inhibiting E. coli adhesion. Overall, these results show that lycopene may be a promising component for the prevention and treatment of colitis.
科研通智能强力驱动
Strongly Powered by AbleSci AI