神经影像学
医学
磁共振弥散成像
白质
痴呆
认知
神经科学
物理医学与康复
放射科
疾病
磁共振成像
病理
精神科
心理学
作者
Maria Clara Zanon Zotin,Pınar Yilmaz,Lukas Sveikata,Dorothée Schoemaker,Susanne J. van Veluw,Mark R. Etherton,Andreas Charidimou,Steven M. Greenberg,Marco Duering,Anand Viswanathan
出处
期刊:Radiology
[Radiological Society of North America]
日期:2023-03-01
卷期号:306 (3)
被引量:3
标识
DOI:10.1148/radiol.212780
摘要
A leading cause of white matter (WM) injury in older individuals is cerebral small vessel disease (SVD). Cerebral SVD is the most prevalent vascular contributor to cognitive impairment and dementia. Therapeutic progress for cerebral SVD and other WM disorders depends on the development and validation of neuroimaging markers suitable as outcome measures in future interventional trials. Diffusion-tensor imaging (DTI) is one of the best-suited MRI techniques for assessing the extent of WM damage in the brain. But the optimal method to analyze individual DTI data remains hindered by labor-intensive and time-consuming processes. Peak width of skeletonized mean diffusivity (PSMD), a recently developed fast, fully automated DTI marker, was designed to quantify the WM damage secondary to cerebral SVD and reflect related cognitive impairment. Despite its promising results, knowledge about PSMD is still limited in the radiologic community. This focused review provides an overview of the technical details of PSMD while synthesizing the available data on its clinical and neuroimaging associations. From a critical expert viewpoint, the authors discuss the limitations of PSMD and its current validation status as a neuroimaging marker for vascular cognitive impairment. Finally, they point out the gaps to be addressed to further advance the field. © RSNA, 2023 Supplemental material is available for this article.
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