去细胞化
伤口愈合
细胞外基质
自愈水凝胶
皮肤修复
生物相容性
真皮
生物医学工程
血管生成
皮肤当量
体内
肌成纤维细胞
化学
材料科学
医学
病理
癌症研究
外科
体外
角质形成细胞
纤维化
生物
有机化学
生物技术
生物化学
作者
Yaling Yu,Huimin Xiao,Guoke Tang,Hongshu Wang,Junjie Shen,Yi Sun,Shuaiqun Wang,Wei Kong,Yimin Chai,Xuanzhe Liu,Xing Wang,Gen Wen
标识
DOI:10.1016/j.mtbio.2023.100725
摘要
Cutaneous wound healing affecting millions of people worldwide represents an unsolvable clinical issue that is frequently challenged by scar formation with dramatical pain, impaired mobility and disfigurement. Herein, we prepared a kind of light-sensitive decellularized dermal extracellular matrix-derived hydrogel with fast gelling performance, biomimetic porous microstructure and abundant bioactive functions. On account of its excellent cell biocompatibility, this ECM-derived hydrogel could induce a marked cellular infiltration and enhance the tube formation of HUVECs. In vivo experiments based upon excisional wound splinting model showed that the hydrogel prominently imparted skin wound healing, as evidenced by notably increased skin appendages and well-organized collagen expression, coupled with significantly enhanced angiogenesis. Moreover, the skin regeneration mediated by this bioactive hydrogel was promoted by an accelerated M1-to-M2 macrophage phenotype transition. Consequently, the decellularized dermal matrix-derived bioactive hydrogel orchestrates the entire skin healing microenvironment to promote wound healing and will be of high value in treatment of cutaneous wound healing. As such, this biomimetic ddECMMA hydrogel provides a promising versatile opinion for the clinical translation.
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