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Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis

医学 改良兰金量表 溶栓 冲程(发动机) 内科学 优势比 血压 心脏病学 逻辑回归 缺血性中风 心肌梗塞 缺血 机械工程 工程类
作者
Lina Palaiodimou,Raed A. Joundi,Aristeidis H. Katsanos,Niaz Ahmed,Joon‐Tae Kim,Nitin Goyal,Ilko Maier,Adam de Havenon,Mohammad Anadani,Marius Matusevicius,Eva Mistry,Pooja Khatri,Adam S Arthur,Amrou Sarraj,Shadi Yaghi,Ashkan Shoamanesh,Luciana Catanese,Marios‐Nikos Psychogios,Konark Malhotra,Alejandro M Spiotta,Sofia Vassilopoulou,Κonstantinos Tsioufis,Else Charlotte Sandset,Andrei V. Alexandrov,Nils Petersen,Georgios Tsivgoulis
出处
期刊:European stroke journal [SAGE]
标识
DOI:10.1177/23969873231211157
摘要

Introduction: Data on the association between blood pressure variability (BPV) after endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) and outcomes are limited. We sought to identify whether BPV within the first 24 hours post EVT was associated with key stroke outcomes. Methods: We combined individual patient-data from five studies among AIS-patients who underwent EVT, that provided individual BP measurements after the end of the procedure. BPV was estimated as either systolic-BP (SBP) standard deviation (SD) or coefficient of variation (CV) over 24 h post-EVT. We used a logistic mixed-effects model to estimate the association [expressed as adjusted odds ratios (aOR)] between tertiles of BPV and outcomes of 90-day mortality, 90-day death or disability [modified Rankin Scale-score (mRS) > 2], 90-day functional impairment (⩾1-point increase across all mRS-scores), and symptomatic intracranial hemorrhage (sICH), adjusting for age, sex, stroke severity, co-morbidities, pretreatment with intravenous thrombolysis, successful recanalization, and mean SBP and diastolic-BP levels within the first 24 hours post EVT. Results: There were 2640 AIS-patients included in the analysis. The highest tertile of SBP-SD was associated with higher 90-day mortality (aOR:1.44;95% CI:1.08–1.92), 90-day death or disability (aOR:1.49;95% CI:1.18–1.89), and 90-day functional impairment (adjusted common OR:1.42;95% CI:1.18–1.72), but not with sICH (aOR:1.22;95% CI:0.76–1.98). Similarly, the highest tertile of SBP-CV was associated with higher 90-day mortality (aOR:1.33;95% CI:1.01–1.74), 90-day death or disability (aOR:1.50;95% CI:1.19–1.89), and 90-day functional impairment (adjusted common OR:1.38;95% CI:1.15–1.65), but not with sICH (aOR:1.33;95% CI:0.83–2.14). Conclusions: BPV after EVT appears to be associated with higher mortality and disability, independently of mean BP levels within the first 24 h post EVT. BPV in the first 24 h may be a novel target to improve outcomes after EVT for AIS.
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