惠普尔病
惠普雷
惠普尔病
疾病
葡萄膜炎
医学
病菌
鉴别诊断
诊断试验
免疫学
发病机制
皮肤病科
病理
儿科
腹腔疾病
肠道吸收不良
出处
期刊:Current Opinion in Ophthalmology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-10-13
卷期号:35 (1): 83-88
标识
DOI:10.1097/icu.0000000000000989
摘要
Purpose of review Whipple's disease is an infectious cause of uveitis that may present with nonspecific findings of intraocular inflammation, which can precede the development of neurologic symptoms and signs. Whipple's disease, then, may evade consideration in the differential diagnosis for uveitis. Recent findings Molecular tests can be helpful in identifying the presence of Tropheryma whipplei from ocular specimens. The application of metagenomic sequencing for ocular specimens is promising, as it offers the opportunity to identify the pathogen when suspicion for an intraocular infection is high. Whipple's disease demonstrates the ability to abrogate the host immune response, which gives some insight into its pathogenesis. Summary Whipple's disease should be suspected in patients who have uveitis refractory to anti-inflammatory therapy. Knowledge of this important pathogen can help direct the timely implementation of diagnostic testing.
科研通智能强力驱动
Strongly Powered by AbleSci AI