Ultrasound and clinicopathological characteristics-based model for prediction of pathologic response to neoadjuvant chemotherapy in HER2-positive breast cancer: a case–control study

乳腺癌 医学 肿瘤科 阶段(地层学) 接收机工作特性 单变量分析 内科学 化疗 癌症 多元分析 曲妥珠单抗 曲线下面积 生物 古生物学
作者
Sui Lin,Yuqi Yan,Tian Jiang,Di Ou,Chen Chen,Min Lai,Ni Chen,Xi Zhu,Liping Wang,Chen Yang,Wei Li,Jincao Yao,Dong Xu
出处
期刊:Breast Cancer Research and Treatment [Springer Science+Business Media]
卷期号:202 (1): 45-55 被引量:4
标识
DOI:10.1007/s10549-023-07057-0
摘要

Abstract Background The objective of this study was to develop a model combining ultrasound (US) and clinicopathological characteristics to predict the pathologic response to neoadjuvant chemotherapy (NACT) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Materials and methods This is a retrospective study that included 248 patients with HER2-positive breast cancer who underwent NACT from March 2018 to March 2022. US and clinicopathological characteristics were collected from all patients in this study, and characteristics obtained using univariate analysis at p < 0.1 were subjected to multivariate analysis and then the conventional US and clinicopathological characteristics independently associated with pathologic complete response (pCR) from the analysis were used to develop US models, clinicopathological models, and their combined models by the area under the receiver operating characteristic (ROC) curve (AUC), accuracy, sensitivity, and specificity to assess their predictive efficacy. Results The combined model had an AUC of 0.808, a sensitivity of 88.72%, a specificity of 60.87%, and an accuracy of 75.81% in predicting pCR of HER2-positive breast cancer after NACT, which was significantly better than the clinicopathological model (AUC = 0.656) and the US model (AUC = 0.769). In addition, six characteristics were screened as independent predictors, namely the Clinical T stage, Clinical N stage, PR status, posterior acoustic, margin, and calcification. Conclusion The conventional US combined with clinicopathological characteristics to construct a combined model has a good diagnostic effect in predicting pCR in HER2-positive breast cancer and is expected to be a useful tool to assist clinicians in effectively determining the efficacy of NACT in HER2-positive breast cancer patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
我是老大应助欣喜眼神采纳,获得10
1秒前
雪落你看不见完成签到,获得积分10
1秒前
嘿嘿应助LYB吕采纳,获得10
2秒前
3秒前
Qwe发布了新的文献求助10
4秒前
隐形曼青应助宋宋采纳,获得10
5秒前
田様应助45采纳,获得10
5秒前
蜂蜜罐zi完成签到,获得积分10
6秒前
搜集达人应助魏少爷采纳,获得10
6秒前
FashionBoy应助冬至季采纳,获得10
6秒前
Yuntao_Chen发布了新的文献求助10
6秒前
6秒前
鸭梨鸭梨发布了新的文献求助10
9秒前
9秒前
火星上书本完成签到,获得积分20
10秒前
科研通AI2S应助sciDoge采纳,获得10
11秒前
吴祥坤发布了新的文献求助10
11秒前
12秒前
量子星尘发布了新的文献求助10
14秒前
14秒前
14秒前
14秒前
15秒前
感谢大家完成签到,获得积分10
16秒前
WQ发布了新的文献求助10
17秒前
hai完成签到,获得积分10
18秒前
18秒前
眯眯眼的雪莲完成签到 ,获得积分10
19秒前
20秒前
天气好好发布了新的文献求助10
20秒前
20秒前
小六九完成签到 ,获得积分10
21秒前
22秒前
22秒前
23秒前
25秒前
冬至季发布了新的文献求助10
26秒前
英吉利25发布了新的文献求助10
27秒前
27秒前
WQ完成签到,获得积分10
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975814
求助须知:如何正确求助?哪些是违规求助? 3520123
关于积分的说明 11201020
捐赠科研通 3256502
什么是DOI,文献DOI怎么找? 1798347
邀请新用户注册赠送积分活动 877523
科研通“疑难数据库(出版商)”最低求助积分说明 806417