药代动力学
体内分布
生物分析
药品
药物输送
药理学
单克隆抗体
毒性
分布(数学)
抗体-药物偶联物
结合
化学
计算生物学
医学
抗体
生物
免疫学
生物化学
数学分析
数学
有机化学
色谱法
体外
作者
Siddhanth Hejmady,Rajesh Pradhan,Shobha Kumari,Meghna Pandey,Sunil Kumar Dubey,Rajeev Taliyan
出处
期刊:Bioanalysis
[Newlands Press Ltd]
日期:2023-09-19
卷期号:15 (19): 1193-1202
被引量:2
标识
DOI:10.4155/bio-2023-0104
摘要
Antibody–drug conjugates (ADCs) is one of the fastest-growing drug-delivery systems. It involves a monoclonal antibody conjugated with payload via a ligand that directly targets the expressive protein of diseased cell. Hence, it reduces systemic exposure and provides site-specific delivery along with reduced toxicity. Because of this advantage, researchers have gained interest in this novel system. ADCs have displayed great promise in drug delivery and biomedical applications. However, a lack of understanding exists on their mechanisms of biodistribution, metabolism and side effects. To gain a better understanding of the therapeutics, careful consideration of the pharmacokinetics and toxicity needs to be undertaken. In this review, different pharmacokinetics parameters including distribution, bioanalysis and heterogeneity are discussed for developing novel therapeutics.
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