神经肽1
肾
体内
纤维化
癌症研究
体外
化学
医学
生物
内科学
血管内皮生长因子
生物化学
生物技术
血管内皮生长因子受体
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2023-12-01
卷期号:325 (6): F870-F884
被引量:1
标识
DOI:10.1152/ajprenal.00069.2023
摘要
Although a few studies have confirmed the correlation between neuropilin 1 (NRP1) and renal diseases, the mechanism of NRP1 in renal fibrosis remains unclear. Here, we investigated the effects of NRP1 on renal fibrosis through in vitro and in vivo experiments and explored the possible downstream mechanisms. We found that NRP1 can stimulate the TGF-β1 signaling pathway, possibly by binding to RACK1, thereby promoting renal fibrosis.
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