医学
心脏结节病
结节病
心力衰竭
内科学
心脏病学
作者
Daichi Maeda,Yuya Matsue,Yuya Matsue,Tsutomu Sunayama,Takashi Iso,Kenji Yamagata,Takeru Nabeta,Yoshihisa Naruse,Takeshi Kitai,Takao Taniguchi,Hidekazu Tanaka,Takahiro Okumura,Yuichi Baba,Tohru Minamino
摘要
ABSTRACT Aim Data on the clinical features and prognosis of patients with isolated cardiac sarcoidosis (iCS) are limited. This study evaluated the clinical characteristics and prognostic impact of iCS. Methods and results This was a secondary analysis of the ILLUMINATE‐CS study, a multicentre, retrospective registry investigating the clinical characteristics and prognosis of cardiac sarcoidosis. iCS was diagnosed according to the 2016 Japanese Circulation Society (JCS) guidelines. Clinical characteristics and prognosis were compared between patients with iCS and systemic cardiac sarcoidosis (sCS). The primary outcome was a combined endpoint of all‐cause death, hospitalization for heart failure, or fatal ventricular arrhythmia events. Among 475 patients with CS (mean age, 62.0 ± 10.9 years; female ratio, 59%) diagnosed by the JCS guidelines, 119 (25.1%) were diagnosed with iCS. Patients with iCS had a higher prevalence of a history of atrial fibrillation or hospitalization for heart failure, or lower left ventricular ejection fraction than those with sCS. During a median follow‐up of 42.3 (interquartile range, 22.8–72.5) months, 141 primary outcomes (29.7%) occurred. Cox proportional hazard analysis revealed that iCS was a significant risk factor for the primary outcome in the unadjusted model (hazard ratio [HR] 1.62; 95% confidence interval [CI] 1.12–2.34; p = 0.011). However, this association was not retained after adjustment for other covariates (adjusted HR 1.27; 95% CI 0.86–1.88; p = 0.226). Conclusions Patients with iCS had more impaired cardiovascular function at the time of diagnosis than those with sCS. However, iCS was not independently associated with poor prognosis after adjustment for prognostic factors.
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