Application of Radiomics in the Efficacy Evaluation of Transarterial Chemoembolization for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

Rationale and Objectives

This meta-analysis was aimed at evaluating the predictive value of radiomics in the context of transarterial chemoembolization (TACE) therapeutic response (TR) for hepatocellular carcinoma (HCC) and patients' survival status (SS) and providing favorable evidence for clinical application.

Materials and Methods

We searched for literature in which radiomics was applied to assess the TR of TACE for HCC and the affected patients' survival status across PubMed, Embase, Cochrane Library and Web of Science until Jul 12, 2023. The quality of included literature was evaluated using a radiomics quality score (RQS) approach, and a meta-analysis was conducted using Stata15.0.

Results

Twenty-four studies were included in the analysis. The meta-analysis revealed that the overall concordance-index (C-index) based on radiomics for predicting the TR and SS with TACE was 0.85 and 0.78, respectively. The combined radiomics-clinical model provided the best performance in evaluating the TR and SS associated with TACE. The C-index was 0.93 and 0.88 for TR and 0.84 and 0.80 for SS, in the training and validation sets, respectively. These values were higher than the 0.87 and 0.79 for TR and 0.79 and 0.70 for SS, respectively with the radiomics model, and 0.71 and 0.66 for TR and 0.72 and 0.66 for SS, respectively with the clinical model.

Conclusion

The radiomics prediction model for the efficacy of TACE in HCC showed a satisfactory prediction performance. The combined radiomics-clinic prediction model had the best performance.