An ultrafast water absorption composite cryogel containing Iron-doped bioactive glass with rapid hemostatic ability for non-compressible and coagulopathic bleeding

止血 复合数 生物相容性 材料科学 生物医学工程 化学 复合材料 医学 外科 冶金
作者
Maocai Li,Qiyuan Dai,Shuangli Zhu,Qi Feng,Zhihao Qin,Huichang Gao,Xiaodong Cao
出处
期刊:Chemical Engineering Journal [Elsevier]
卷期号:469: 143758-143758 被引量:14
标识
DOI:10.1016/j.cej.2023.143758
摘要

Traditional hemostatic materials have limited hemostatic effect on non-compressible wound, that is likely to develop into coagulopathy and leads to high mortality. As a powerful hemostatic material, in addition to having the function of forming solid physical barriers and effectively activating coagulation factors to rapidly control hemostasis, it should also has the ability to bypass the coagulation pathway to handle the bleeding of coagulopathic patients. In this work, we designed a QCOC composite cryogel by gelation of quaternized chitosan (QCS) and hydroxyethyl cellulose oxide (OHEC) at low temperature. Meanwhile, iron-doped bioactive glass (FeBG) as an active substance was introduced into the QCOC composite cryogel to promote erythrocyte aggregation by ion dissolution and activate intrinsic and extrinsic pathways. QCOC/FeBG composite cryogel had interconnected macroporous structure, ultrafast water absorption performance (reaching water absorption saturation in 4 s) and good shape memory properties (restoring to its original shape in 1 s). Additionally, the composite cryogel showed excellent antibacterial properties against S. aureus and E. coli as well as good cell biocompatibility. Furthermore, the QCOC/FeBG composite cryogel showed excellent hemostatic performance in the model of liver non-compressible hemorrhage with coagulation disorders, and the hemostasis time and blood loss were 60.87 ± 2.09 s and 366.38 ± 32.69 mg respectively, which were much lower than commercial gelatin sponge (196.62 ± 19.02 s and 1439.37 ± 165.27 mg). These results proved that QCOC/FeBG composite cryogel has excellent hemostatic properties, antibacterial properties, portability and usability, indicating a great potential as a timely hemostatic material in daily civil and military hemostasis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
阳洋完成签到,获得积分10
2秒前
caicaikan完成签到,获得积分10
3秒前
孝顺的猕猴桃完成签到,获得积分10
4秒前
汉堡包应助Yexidong采纳,获得10
4秒前
华仔应助gdh采纳,获得10
5秒前
6秒前
6秒前
顺心绮兰完成签到,获得积分10
9秒前
无限的冰蝶完成签到,获得积分20
10秒前
领导范儿应助丶氵一生里采纳,获得10
10秒前
拒绝头秃发布了新的文献求助10
11秒前
咖啡续命发布了新的文献求助10
11秒前
15秒前
17秒前
完美世界应助达芙妮采纳,获得10
17秒前
gdh发布了新的文献求助10
21秒前
23秒前
科研通AI2S应助风中的赛凤采纳,获得10
24秒前
24秒前
彭于晏应助小小li采纳,获得10
28秒前
完美世界应助赤岩采纳,获得10
31秒前
科研通AI2S应助wsl采纳,获得10
35秒前
519完成签到,获得积分10
36秒前
36秒前
张宝发布了新的文献求助10
37秒前
38秒前
39秒前
40秒前
七九发布了新的文献求助10
40秒前
43秒前
43秒前
juan发布了新的文献求助30
45秒前
。。。发布了新的文献求助10
45秒前
赤岩发布了新的文献求助10
45秒前
voyager完成签到,获得积分10
46秒前
七九完成签到,获得积分10
48秒前
二师兄给二师兄的求助进行了留言
49秒前
pluto应助dll采纳,获得10
50秒前
51秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3161611
求助须知:如何正确求助?哪些是违规求助? 2812907
关于积分的说明 7897655
捐赠科研通 2471797
什么是DOI,文献DOI怎么找? 1316160
科研通“疑难数据库(出版商)”最低求助积分说明 631222
版权声明 602112