[Research progress of mouse model of hepatitis B virus infection].

Hepatitis B virus (HBV) infection is a global health problem. Animal models are important for the study of the HBV infection mechanism. In the study related to the mouse model of HBV infection, the researchers have established a variety of mouse models, including transgenic, plasmid hydrodynamic injection, virus vector transfection, cccDNA cycle simulation, human and mouse liver chimerism, and liver/immune dual humanization, according to the characteristics of HBV infection. Herein, the research progress of these models is summarized. Notably, the application of these models can further clarify the mechanism of HBV infection under the conditions of a specific immune response in vivo and lay the foundation for the development of new antiviral drugs and immunotherapy for HBV infection.乙型肝炎病毒（HBV）感染是世界范围内存在的健康问题。动物模型对HBV感染机制研究至关重要。在HBV感染小鼠模型的相关研究中，研究者针对HBV感染的特点，建立了包括转基因、质粒流体动力注射、病毒载体转染、cccDNA周期模拟、人鼠肝脏嵌合及肝脏/免疫双人源化等多种小鼠模型。现对这些模型的研究进展进行了总结。应用这些模型，可进一步明确体内特异性免疫反应条件下的HBV感染机制，为开发HBV感染新型抗病毒药物和免疫治疗奠定基础。.