Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C–H Bonds via H/D Exchange with D2O

We report a general approach for efficient deuteration of the metabolically labile α-C-H bonds of widespread amides and amines. Temporarily masking the secondary amine group as a carbamate allows an unprecedented photoredox hydrogen atom transfer-promoted α-carbamyl radical formation for efficient H/D exchange with D