下调和上调
CD36
磷酸化
AKT1型
化学
兴奋剂
对偶(语法数字)
细胞生物学
丝氨酸
部分激动剂
生物化学
受体
生物
基因
蛋白激酶B
艺术
文学类
作者
Xiaobin Cai,Qin Zhang,Wei Wang,Yingying Miao,Yuqing Sun,Ziyin Xia,Luyong Zhang,Qinwei Yu,Zhenzhou Jiang
标识
DOI:10.1021/acs.chemrestox.4c00268
摘要
ZLY06 is a dual agonist of peroxisome proliferator-activated receptor (PPAR) δ/γ, showing potential therapeutic effects on metabolic syndrome. However, our research has revealed that ZLY06 exhibits hepatotoxicity in normal C57BL/6J mice, though the precise mechanism remains unclear. This study aims to investigate the manifestations and mechanisms of ZLY06-induced hepatotoxicity. We administered ZLY06 via oral gavage to C57BL/6J mice (once daily for six weeks) and monitored various indicators to preliminarily explore its hepatotoxicity. Additionally, we further investigate the specific mechanisms of ZLY06-induced hepatotoxicity using PPAR inhibitors (GW9662 and GSK0660) and the Protein kinase B (AKT) activator (SC79). Results showed that ZLY06 led to increased serum ALP, ALT and AST, as well as elevated liver index and hepatic lipid levels. There was upregulation in the gene and protein expression of lipid metabolism-related molecules
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