化学
效力
香豆素
胰腺癌
鉴定(生物学)
药理学
癌症
组合化学
生物化学
体外
有机化学
内科学
医学
植物
生物
作者
Shengnan Zhou,Xiaotong Ze,Dazhi Feng,Lihua Liu,Yuning Shi,Minghui Yu,Lijuan Huang,Yunyue Wang,Hui Men,Jianbing Wu,Zhenwei Yuan,Mengze Zhou,Jinyi Xu,Xinnan Li,Hong Yao
标识
DOI:10.1021/acs.jmedchem.4c01178
摘要
Increasing evidence has demonstrated that oxidative phosphorylation (OXPHOS) is closely associated with the progression of pancreatic cancer (PC). Given its central role in mitochondrial transcription, the human mitochondrial RNA polymerase (POLRMT) is a promising target for developing PC treatments. Herein, structure-activity relationship exploration led to the identification of compound
科研通智能强力驱动
Strongly Powered by AbleSci AI