Systematic review and meta-analysis on the effects of physical activity-based interventions on frailty status and clinical outcomes in adults with long-term cardiac conditions

医学 心理干预 荟萃分析 期限(时间) 老年学 重症监护医学 体力活动 物理疗法 内科学 精神科 物理 量子力学
作者
Shirley Sze,H Waterhouse,Sally Singh,I B Squire
出处
期刊:European Heart Journal [Oxford University Press]
卷期号:45 (Supplement_1)
标识
DOI:10.1093/eurheartj/ehae666.1102
摘要

Abstract Introduction Frailty is common in patients with long-term cardiac conditions and is associated with poor clinical outcomes, but limited treatment options are available. Previous studies investigating interventions for frailty have shown positive results with physical activity interventions, however, these studies were largely based on general elderly populations. Aim To assess the impact of physical activity-based interventions on frailty and clinical outcomes in frail patients with long-term cardiac conditions. Methods A systematic review and meta-analysis was conducted based on the PRISMA guideline, using Medline, Embase, CENTRAL, PEDro, CINAHL electronic databases for articles published between 2000 and 2023. Studies which recruited adults >18 years with long-term cardiac conditions (including angina, acute coronary syndrome (ACS), valve disease, heart failure (HF), atrial fibrillation, cardiac surgery and congenital heart disease) who underwent physical activity-based interventions were included. The primary outcome was change in frailty (measured using a validated tool) post intervention. We also assessed the effect of interventions on mortality and hospitalisation. Results We screened 2697 records and reviewed 91 full-text articles; 12 studies (14 articles) were included, involving 1394 patients. Median age of participants ranged from 64 to 82 years. Five studies recruited participants with HF, 3 evaluated participants post transaortic valve implantation, 3 recruited cardiac surgical patients and 1 study evaluated participants post ACS. Physical activity-based interventions were multi-domain, including a mixture of aerobic, strength, balance, endurance and respiratory muscle training; the majority (N=10) had individualised exercise prescription. Meta-analysis of 8 randomised controlled trials (RCTs) showed statistically significant improvement in frailty associated with physical activity-based interventions compared to controls [pooled standardised mean difference (95% CI) = -0.34 (-0.59 to -0.08), p = 0.01, I2 = 48%]. Seven RCTs evaluated change in frailty by short physical performance battery (SPPB). Meta-analysis of these studies showed a statistically significant improvement in SPPB associated with physical activity-based interventions compared to controls [pooled mean difference (95% CI) = 0.83 (0.31-1.34), p = 0.002, I2 = 49%]. (Figure) The magnitude of improvement in SPPB exceeded the minimally clinically significant improvement of 0.5. Three studies evaluated the effect of physical activity-based intervention on clinical outcomes, all of which showed neutral effect on mortality and hospitalisation. Conclusion Physical activity-based interventions in patients with frailty and long-term cardiac conditions were associated with significant improvement in frailty status, with neutral effect on mortality and hospitalisation. Figure: Meta-analysis of 7 RCTs assessing effect of physical activity-based interventions on SPPB

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
顾矜应助aaggaga采纳,获得10
刚刚
stuffmatter举报Lucky求助涉嫌违规
3秒前
3秒前
大模型应助隐形的皮卡丘采纳,获得10
4秒前
安安完成签到 ,获得积分10
4秒前
Zcccjy发布了新的文献求助10
4秒前
英俊牛排发布了新的文献求助10
9秒前
harry发布了新的文献求助10
10秒前
顾翩翩完成签到,获得积分10
14秒前
bkagyin应助知性的书竹采纳,获得10
14秒前
帅气念梦完成签到 ,获得积分10
16秒前
CodeCraft应助飞快的万声采纳,获得10
17秒前
17秒前
脑洞疼应助nuisance采纳,获得10
19秒前
yun发布了新的文献求助10
19秒前
bole发布了新的文献求助10
20秒前
小楠楠发布了新的文献求助10
20秒前
Gyrate完成签到,获得积分10
21秒前
22秒前
Shishulong发布了新的文献求助10
22秒前
李爱国应助Silence采纳,获得10
22秒前
25秒前
26秒前
27秒前
互助遵法尚德应助ZZRR采纳,获得10
27秒前
YJY完成签到,获得积分10
28秒前
29秒前
31秒前
Richard发布了新的文献求助10
32秒前
一薪发布了新的文献求助10
33秒前
交院发布了新的文献求助10
33秒前
牛肉拉面完成签到,获得积分20
34秒前
星辰大海应助王玄琳采纳,获得10
36秒前
科研的狗完成签到 ,获得积分10
36秒前
37秒前
38秒前
体贴海白发布了新的文献求助20
38秒前
39秒前
共享精神应助科研探索者采纳,获得10
39秒前
半斤发布了新的文献求助10
39秒前
高分求助中
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger Heßler, Claudia, Rud 1000
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 1000
Natural History of Mantodea 螳螂的自然史 1000
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 500
Spatial Political Economy: Uneven Development and the Production of Nature in Chile 400
Research on managing groups and teams 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3329232
求助须知:如何正确求助?哪些是违规求助? 2959017
关于积分的说明 8593599
捐赠科研通 2637442
什么是DOI,文献DOI怎么找? 1443516
科研通“疑难数据库(出版商)”最低求助积分说明 668773
邀请新用户注册赠送积分活动 656119