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The effect of endocrine-disrupting chemicals in follicular fluid: The insights from oocyte to fertilization

卵泡液 卵母细胞 人类受精 内分泌系统 四分位间距 繁殖 卵泡期 胚胎质量 男科 生物 生理学 内分泌学 医学 内科学 激素 细胞生物学 胚胎 生态学 解剖
作者
Jiehao Li,Lixin Zhou,Songyi Huang,Tiantian Duan,Jinying Xie,Xiaojie Li,Langjing Deng,Chenyan Zeng,Fengrui Jing,Sui Zhu,Chaoqun Liu,Yajie Gong,Yaqing Shu,Xiaoting Shen,Pan Yang
出处
期刊:Environment International [Elsevier BV]
卷期号:191: 108957-108957 被引量:3
标识
DOI:10.1016/j.envint.2024.108957
摘要

Endocrine-disrupting chemicals (EDCs) exhibited the detriment in female reproductive health. Our objective was to investigate the individual and mixture effects of EDCs present in follicular fluid, the environment in which oocytes grow and develop, on early reproductive outcomes. We recruited 188 women seeking reproduction examination from the Study of Exposure and Reproductive Health (SEARCH) cohort between December 2020 and November 2021. We assessed the concentrations of 7 categories of 64 EDCs in follicular fluid, and measured early reproductive outcomes, including retrieved oocytes, mature oocytes, normal fertilized oocytes, and high-quality embryos. In this study Monomethyl phthalate (MMP) (2.17 ng/ml) were the compounds found in the highest median concentrations in follicular fluid. After adjusting for multiple testing, multivariate regression showed that multiple EDCs were significantly negatively associated with early assisted reproduction outcomes. For example, MMP showed a significant negative correlation with the number of high quality embryos (β: −0.1, 95 % CI: −0.15, −0.04). Specifically, eight types of EDCs were significantly negatively associated with four early assisted reproductive outcomes (β range: −0.2 ∼ -0.03). In the mixed exposure model, we found that mixtures of EDC were significantly negatively correlated with all four outcomes. In the quantile g-computation (QGCOMP) model, for each interquartile range increase in the concentration of EDC mixtures, the number of oocytes retrieved, mature oocytes, normally fertilized oocytes, and high-quality embryos decreased by 0.46, 0.52, 0.77, and 1.2, respectively. Moreover, we identified that phthalates (PAEs) predominantly contributed to the negative effects. Future research should validate our findings.
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