瓜氨酸化
弹性蛋白
发病机制
翻译后修饰
慢性阻塞性肺病
医学
转化研究
化学
生物
免疫学
遗传学
病理
内科学
瓜氨酸
生物化学
精氨酸
氨基酸
酶
作者
Mark P. Murphy,Marina Zieger,Michaël Henry,Paula Meleady,C. Mueller,Noel G. McElvaney,Emer P. Reeves
出处
期刊:American Journal of Physiology-lung Cellular and Molecular Physiology
[American Physiological Society]
日期:2024-08-13
标识
DOI:10.1152/ajplung.00185.2024
摘要
Elastin is an extracellular matrix protein (ECM) that supports elasticity of the lung, and in patients with chronic obstructive pulmonary disease (COPD) and emphysema, the structural changes that reduce the amount of elastic recoil, lead to loss of pulmonary function. We recently demonstrated that elastin is a target of peptidyl arginine deiminase (PAD) enzyme-induced citrullination, thereby leading to enhanced susceptibility of this ECM protein to proteolysis. The current study aimed to investigate the impact of PAD activity
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