姜黄素
细胞凋亡
脾脏
免疫系统
药理学
免疫学
背景(考古学)
生物
细胞色素c
半胱氨酸蛋白酶3
抗体
生物化学
程序性细胞死亡
古生物学
作者
Azhar Muhmood,Бо Лю,Dandan Liu,Shuiping Liu,Mahmoud M. Azzam,Muhammad Junaid,Lili Hou,Guannan Le,Kehe Huang
出处
期刊:Toxins
[MDPI AG]
日期:2024-08-13
卷期号:16 (8): 356-356
标识
DOI:10.3390/toxins16080356
摘要
In the context of the potential immunomodulatory properties of curcumin in counteracting the detrimental effects of concurrent exposure to Deoxynivalenol (DON) and Aflatoxin B1 (AFB1), a comprehensive 28-days trial was conducted utilizing 60 randomly allocated mice divided into four groups. Administration of curcumin at a dosage of 5 mg/kg body weight in conjunction with DON at 0.1 mg/kg and AFB1 at 0.01 mg/kg body weight was undertaken to assess its efficacy. Results indicated that curcumin intervention demonstrated mitigation of splenic structural damage, augmentation of serum immunoglobulin A (IgA) and immunoglobulin G (IgG) levels, elevation in T lymphocyte subset levels, and enhancement in the mRNA expression levels of pro-inflammatory cytokines TNF-α, IFN-γ, IL-2, and IL-6. Furthermore, curcumin exhibited a suppressive effect on apoptosis in mice, as evidenced by decreased activity of caspase-3 and caspase-9, reduced expression levels of pro-apoptotic markers Bax and Cytochrome-c (Cyt-c) at both the protein and mRNA levels, and the maintenance of a balanced expression ratio of mitochondrial apoptotic regulators Bax and Bcl-2. Collectively, these findings offer novel insights into the therapeutic promise of curcumin in mitigating immunosuppression and apoptotic events triggered by mycotoxin co-exposure.
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