Outcome after surgery for invasive intraductal papillary mucinous neoplasia compared to conventional pancreatic ductal adenocarcinoma – A Swedish nationwide register-based study

医学 导管内乳头状粘液性肿瘤 比例危险模型 阶段(地层学) 内科学 队列 腺癌 胰腺癌 胃肠病学 胰腺导管腺癌 切除缘 肿瘤科 生存分析 人口 癌症登记处 癌症 外科 胰腺 切除术 古生物学 环境卫生 生物
作者
Marcus Holmberg,Cecilia Radkiewicz,C. Strömberg,Mikael Öman,Poya Ghorbani,Matthias Löhr,Ernesto Sparrelid
出处
期刊:Pancreatology [Elsevier BV]
卷期号:23 (1): 90-97 被引量:3
标识
DOI:10.1016/j.pan.2022.12.003
摘要

The clinical importance of intraductal papillary mucinous neoplasm (IPMN) have increased last decades. Long-term survival after resection for invasive IPMN (inv-IPMN) compared to conventional pancreatic ductal adenocarcinoma (PDAC) is not thoroughly delineated. This study, based on the Swedish national pancreatic and periampullary cancer registry aims to elucidate the outcome after resection of inv-IPMN compared to PDAC. All patients ≥18 years of age resected for inv-IPMN and PDAC in Sweden between 2010 and 2019 were included. Clinicopathological variables were retrieved from the national registry. The effect on death was assessed in two multivariable Cox regression models, one for patients resected 2010–2015, one for patients resected 2016–2019. Median overall survival (OS) was estimated using the Kaplan-Meier method. We included 1909 patients, 293 inv-IPMN and 1616 PDAC. The most important independent predictors of death in multivariable Cox regressions were CA19-9 levels, venous resection, tumour differentiation, as well as T-, N-, M-stage and surgical margin. Tumour type was an independent predictor for death in the 2016–2019 cohort, but not in the 2010–2015 cohort. In Kaplan-Meier survival analysis, inv-IPMN was associated with longer median OS in stage N0-1 and in stage M0 compared to PDAC. However, in stage T2-4 and stage N2 median OS was similar, and in stage M1 even shorter for inv-IPMN compared to PDAC. In this population-based nationwide study, outcome after resected inv-IPMN compared to PDAC is more favourable in lower stages, and similar to worse in higher.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
小蘑菇应助小心科研采纳,获得10
刚刚
renxy应助Avert.采纳,获得10
刚刚
科研通AI2S应助loser采纳,获得10
1秒前
外向的飞雪完成签到,获得积分10
1秒前
善良豌豆完成签到,获得积分20
1秒前
嗷嗷嗷啊发布了新的文献求助10
1秒前
znn发布了新的文献求助10
2秒前
3秒前
HIT_C发布了新的文献求助10
3秒前
musejie应助江左1998采纳,获得10
3秒前
量子星尘发布了新的文献求助10
4秒前
4秒前
黄瓜儿完成签到,获得积分10
5秒前
高山我梦发布了新的文献求助10
7秒前
7秒前
7秒前
深情安青应助缥缈的铅笔采纳,获得10
8秒前
8秒前
Akim应助鱼咬羊采纳,获得10
8秒前
9秒前
9秒前
轻松的亦寒应助wf0923采纳,获得30
10秒前
QW111发布了新的文献求助10
11秒前
老迟到的小蘑菇完成签到,获得积分10
11秒前
drgaoying发布了新的文献求助10
12秒前
LJL发布了新的文献求助10
12秒前
向日葵完成签到,获得积分10
13秒前
Deerlu完成签到,获得积分10
13秒前
13秒前
刘欣发布了新的文献求助30
14秒前
cj完成签到,获得积分10
14秒前
张彩红完成签到,获得积分10
14秒前
ZGAAQj完成签到 ,获得积分10
14秒前
上官若男应助Brucewang1127采纳,获得10
14秒前
15秒前
15秒前
15秒前
16秒前
直率千愁完成签到,获得积分10
16秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974643
求助须知:如何正确求助?哪些是违规求助? 3519094
关于积分的说明 11196979
捐赠科研通 3255182
什么是DOI,文献DOI怎么找? 1797700
邀请新用户注册赠送积分活动 877100
科研通“疑难数据库(出版商)”最低求助积分说明 806130