类有机物
转移
血管生成
循环肿瘤细胞
癌症
肿瘤微环境
癌症研究
体内
个性化医疗
生物
医学
肿瘤细胞
生物信息学
神经科学
内科学
生物技术
作者
Yang Du,Yi‐Ran Wang,Qiyuan Bao,Xinxin Xu,Congling Xu,Shaoxuan Wang,Qi Liu,Fan Liu,Yi Zeng,Yajun Wang,Wei Liu,Yixin Liu,Sai‐Xi Yu,Yu‐Chen Chen,Chen Wang,Weibin Zhang,Hai Gao,Hao Luo,Baohong Liu,Guangyin Jing,Ming Guo,Fei Chen,Yan‐Jun Liu
标识
DOI:10.1002/adma.202412815
摘要
Abstract While tumor organoids have revolutionized cancer research by recapitulating the cellular architecture and behaviors of real tumors in vitro, their lack of functional vasculature hinders their attainment of full physiological capabilities. Current efforts to vascularize organoids are struggling to achieve well‐defined vascular networks, mimicking the intricate hierarchy observed in vivo, which restricts the physiological relevance particularly for studying tumor progression and response to therapies targeting the tumor vasculature. An innovative vascularized patient‐derived tumor organoids (PDTOs)‐on‐a‐chip with hierarchical, tumor‐specific microvasculature is presented, providing a versatile platform to explore tumor‐vascular dynamics and antivascular drug efficacy. It is found that highly metastatic tumor cells induced vessel angiogenesis and simultaneously migrated toward blood vessels via the Notch pathway. The evident association between the angiogenic and migratory capacities of PDTOs and their clinical metastatic outcomes underscores the potential of the innovative platform for evaluating tumor metastasis, thus offering valuable insights for clinical decision‐making. Ultimately, the system represents a promising avenue for advancing the understanding of tumor metastasis and developing personalized treatment strategies based on patient‐specific tumor characteristics.
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