Amelioration of tableting properties and dissolution rate of naproxen co-grinded with nicotinamide: Preparation and characterization of co-grinded mixture

Reducing the dimensions, when other additives are present, shows potential as a method to improve the dissolution and solubility of BCS class II drugs that have poor solubility. In this investigation, the process involved grinding naproxen with nicotinamide with the aim of improving solubility and the rate of dissolution.