Hyperglycemia Inhibits Hepatic SHBG Synthesis Through the NGBR‐AMPK‐HNF4 Pathway in Rats with Polycystic Ovary Syndrome Induced by Letrozole in Combination with a High‐Fat Diet

Polycystic ovary syndrome (PCOS) is closely related to non-alcoholic fatty liver disease (NAFLD), and sex hormone-binding globulin (SHBG) is a glycoprotein produced by the liver. Hepatic lipogenesis inhibits hepatic SHBG synthesis, which leads to hyperandrogenemia and ovarian dysfunction in PCOS. Therefore, this study aims to characterize the mechanism whereby liver lipogenesis inhibits SHBG synthesis.