糖基化
子宫内膜异位症
子宫内膜
子宫内膜癌
不育
月经
疾病
医学
癌症研究
生物
妇科
肿瘤科
生物信息学
怀孕
癌症
内科学
生物化学
遗传学
作者
Linyu Zhang,Ying Feng,Yue Zhang,Xinrui Sun,Qianhong Ma,Fang Ma
出处
期刊:Biomolecules
[MDPI AG]
日期:2024-06-27
卷期号:14 (7): 770-770
摘要
The endometrium is an important part of women’s bodies for menstruation and pregnancy. Various proteins are widely expressed on the surface of endometrial cells, and glycosylation is an important post-translational modification of proteins. Glycosylation modification is closely related not only to endometrial receptivity but also to common diseases related to endometrial receptivity. Glycosylation can improve endometrial receptivity, promote embryo localization and trophoblast cell adhesion and invasion, and contribute to successful implantation. Two diseases related to endometrial receptivity include endometriosis and endometrial cancer. As a common benign disease in women, endometriosis is often accompanied by an increased menstrual volume, prolonged menstrual periods, progressive and aggravated dysmenorrhea, and may be accompanied by infertility. Protein glycosylation modification of the endometrial surface indicates the severity of the disease and may be an important pathogenesis of endometriosis. In cancer, glycosylation modifications on the surface of tumor cells can be a marker to distinguish the type and severity of endometrial cancer. This review highlights the role of protein glycosylation in embryo–maternal endometrial dialogue and explores its potential mechanisms in diseases related to endometrial receptivity, which could provide a new clinical approach for their diagnosis and treatment.
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