The Sweet Relationship between the Endometrium and Protein Glycosylation

糖基化 子宫内膜异位症 子宫内膜 子宫内膜癌 不育 月经 疾病 医学 癌症研究 生物 妇科 肿瘤科 生物信息学 怀孕 癌症 内科学 生物化学 遗传学
作者
Linyu Zhang,Ying Feng,Yue Zhang,Xinrui Sun,Qianhong Ma,Fang Ma
出处
期刊:Biomolecules [MDPI AG]
卷期号:14 (7): 770-770
标识
DOI:10.3390/biom14070770
摘要

The endometrium is an important part of women’s bodies for menstruation and pregnancy. Various proteins are widely expressed on the surface of endometrial cells, and glycosylation is an important post-translational modification of proteins. Glycosylation modification is closely related not only to endometrial receptivity but also to common diseases related to endometrial receptivity. Glycosylation can improve endometrial receptivity, promote embryo localization and trophoblast cell adhesion and invasion, and contribute to successful implantation. Two diseases related to endometrial receptivity include endometriosis and endometrial cancer. As a common benign disease in women, endometriosis is often accompanied by an increased menstrual volume, prolonged menstrual periods, progressive and aggravated dysmenorrhea, and may be accompanied by infertility. Protein glycosylation modification of the endometrial surface indicates the severity of the disease and may be an important pathogenesis of endometriosis. In cancer, glycosylation modifications on the surface of tumor cells can be a marker to distinguish the type and severity of endometrial cancer. This review highlights the role of protein glycosylation in embryo–maternal endometrial dialogue and explores its potential mechanisms in diseases related to endometrial receptivity, which could provide a new clinical approach for their diagnosis and treatment.
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