Circulating metabolic biomarkers and risk of new-onset hypertension: findings from the UK Biobank

医学 生命银行 内科学 生物信息学 生物
作者
Yanfeng Zhou,Yi-Xiang Ye,Jun‐Xiang Chen,Yanbo Zhang,Yi Wang,Qi Lu,Tingting Geng,Gang Liu,An Pan
出处
期刊:Journal of Hypertension [Ovid Technologies (Wolters Kluwer)]
卷期号:42 (6): 1066-1074 被引量:1
标识
DOI:10.1097/hjh.0000000000003697
摘要

Objective: The evidence regarding the associations of circulating metabolic biomarkers with hypertension risk is scarce. We aimed to examine the associations between circulating metabolites and risk of hypertension. Methods: We included 49 422 individuals free of hypertension at baseline with a mean (SD) age of 53.5 (8.0) years from the UK Biobank. Nuclear magnetic resonance spectroscopy was used to quantify 143 individual metabolites. Multivariable-adjusted Cox regression models were used to estimate hazard ratios and 95% confidence intervals (CIs). Results: During a mean (SD) follow-up of 11.2 (1.8) years, 2686 incident hypertension cases occurred. Out of 143 metabolites, 76 were associated with incident hypertension, among which phenylalanine (hazard ratio: 1.40; 95% CI: 1.24–1.58) and apolipoprotein A1 (hazard ratio: 0.76; 95% CI: 0.66–0.87) had the strongest association when comparing the highest to the lowest quintile. In general, very-low-density lipoprotein (VLDL) particles were positively, whereas high-density lipoprotein (HDL) particles were inversely associated with risk of hypertension. Similar patterns of cholesterol, phospholipids, and total lipids within VLDL and HDL particles were observed. Triglycerides within all lipoproteins were positively associated with hypertension risk. Other metabolites showed significant associations with risk of hypertension included amino acids, fatty acids, ketone bodies, fluid balance and inflammation markers. Adding 10 selected metabolic biomarkers to the traditional hypertension risk model modestly improved discrimination (C-statistic from 0.745 to 0.752, P < 0.001) for prediction of 10-year hypertension incidence. Conclusion: Among UK adults, disturbances in metabolic biomarkers are associated with incident hypertension. Comprehensive metabolomic profiling may provide potential novel biomarkers to identify high-risk individuals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小蘑菇应助hh采纳,获得10
1秒前
赵小楠完成签到,获得积分10
2秒前
2秒前
荼白发布了新的文献求助20
4秒前
科研通AI2S应助xiewuhua采纳,获得10
5秒前
hu发布了新的文献求助30
6秒前
ily.完成签到,获得积分10
6秒前
6秒前
yaoyaoyao完成签到 ,获得积分10
6秒前
NuLi完成签到 ,获得积分10
7秒前
JamesPei应助勤劳篮球采纳,获得10
7秒前
暮暮完成签到,获得积分10
9秒前
大模型应助Leo000007采纳,获得10
10秒前
11秒前
11秒前
yyd完成签到,获得积分10
11秒前
11秒前
11秒前
12秒前
bkagyin应助shanbaibai采纳,获得10
13秒前
ppy完成签到 ,获得积分10
13秒前
13秒前
15秒前
Orange应助Dreamer采纳,获得10
15秒前
15秒前
苏同学发布了新的文献求助10
16秒前
yangsi发布了新的文献求助10
16秒前
赵小楠发布了新的文献求助10
17秒前
17秒前
大气摩托发布了新的文献求助10
17秒前
大气摩托发布了新的文献求助10
17秒前
大气摩托发布了新的文献求助10
18秒前
优雅的盼夏完成签到 ,获得积分10
20秒前
Able发布了新的文献求助10
21秒前
勤劳篮球发布了新的文献求助10
22秒前
23秒前
23秒前
麦兜完成签到 ,获得积分10
24秒前
25秒前
25秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3248499
求助须知:如何正确求助?哪些是违规求助? 2891839
关于积分的说明 8268971
捐赠科研通 2559871
什么是DOI,文献DOI怎么找? 1388724
科研通“疑难数据库(出版商)”最低求助积分说明 650815
邀请新用户注册赠送积分活动 627782