A Porous Hydrogen‐Bonded Organic Framework Material for the Sustained Release of Ibuprofen

Abstract Design and synthesis of drug delivery carrier for targeted and controlled drug release is very vital but challenging. In this work, based on organic ligand molecule 2,4,6‐tris(4‐carboxyphenyl)aniline (BTB‐NH 2 ), a porous hydrogen‐bonded organic framework material HOF‐BTB‐NH 2 was designed and synthesized for targeted drug delivery. The anti‐inflammatory drug Ibuprofen (IBU) was effectively loaded in the HOF‐BTB‐NH 2 , and it took 6 hours to release IBU completely in PBS buffer solution. This work demonstrates that the porous HOF materials are promising candidates for targeted drug delivery applications.