Characterization of the volatile profile and its estrogenic activity in Kadsura coccinea fruit

化学 植物雌激素 传统医学 雌激素 食品科学 生物 医学 内分泌学
作者
Jin-jin Dong,Jie-yao Ma,Weiye Yang,Wei Cai,Weihua Wu
出处
期刊:Journal of Ethnopharmacology [Elsevier BV]
卷期号:309: 116341-116341 被引量:29
标识
DOI:10.1016/j.jep.2023.116341
摘要

The fruit of Kadsura coccinea (Lem.) A. C. Smith is an ethnomedicine used to treat abnormal menstruation, menopausal syndrome, and female infertility among the Dong Nationality in China.Our study aimed to identify the volatile oil profiles of the K. coccinea fruit and elucidate their estrogenic activity.The peel volatile oil (PeO), pulp volatile oil (PuO), and seed volatile oil (SeO) of K. coccinea were extracted using hydrodistillation and qualitatively analyzed using gas chromatography-mass spectrometry (GC-MS). Estrogenic activity was evaluated in vitro using cell assay and in vivo using immature female rats. Serum 17β-Estradiol (E2) and follicle-stimulating hormone (FSH) levels were detected using ELISA.In total, 46 PeO, 27 PuO, and 42 SeO components representing 89.96%, 90.19%, and 97% of the total composition, respectively, were identified. The compounds with the highest content in PeO, PuO, and SeO were β-caryophyllene, γ-amorphene, and n-hexadecanoic acid, respectively. PeO induced proliferation of MCF-7 cells with an EC50 of 7.40 μg/mL. Subcutaneous administration of 10 mg/kg PeO significantly increased the weight of the uteri in immature female rats, with no effect on serum E2 and FSH levels. PeO acted as an agonist of ERα and ERβ. PuO and SeO showed no estrogenic activity.The chemical compositions of PeO, PuO, and SeO of K. coccinea are different. PeO is the main effective fraction for estrogenic activities, providing a new source of phytoestrogen for the treatment of menopausal symptoms.
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