外渗
转移
癌症转移
医学
肿瘤科
癌症研究
内科学
病理
癌症
作者
Tatiana S. Gerashchenko,A. A. Schegoleva,Anna A. Khozyainova,Е. Л. Чойнзонов,Evgeny V. Denisov
标识
DOI:10.1016/j.bbcan.2023.188867
摘要
Despite considerable advances in the evolution of anticancer therapies, metastasis still remains the main cause of cancer mortality. Therefore, current strategies for cancer cure should be redirected towards prevention of metastasis. Targeting metastatic pathways represents a promising therapeutic opportunity aimed at obstructing tumor cell dissemination and metastatic colonization. In this review, we focus on preclinical studies and clinical trials over the last five years that showed high efficacy in suppressing metastasis through targeting lymph node dissemination, tumor cell extravasation, reactive oxygen species, pre-metastatic niche, exosome machinery, and dormancy.
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