Aspergillus and progression of lung disease in children with cystic fibrosis

医学 囊性纤维化 支气管扩张 支气管肺泡灌洗 空气滞留 肺功能测试 内科学 呼吸道疾病 人口 胃肠病学 曲霉 病理 植物 生物 环境卫生
作者
Sabariah Noor Harun,Claire Wainwright,Keith Grimwood,Stefanie Hennig
出处
期刊:Thorax [BMJ]
卷期号:74 (2): 125-131 被引量:33
标识
DOI:10.1136/thoraxjnl-2018-211550
摘要

The impact of Aspergillus on lung disease in young children with cystic fibrosis is uncertain.To determine if positive respiratory cultures of Aspergillus species are associated with: (1) increased structural lung injury at age 5 years; (2) accelerated lung function decline between ages 5 years and 14 years and (3) to identify explanatory variables.A cross-sectional analysis of association between Aspergillus positive bronchoalveolar lavage (BAL) cultures and chest high-resolution CT (HRCT) scan findings at age 5 years in subjects from the Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) study was performed. A non-linear mixed-effects disease progression model was developed using FEV1% predicted measurements at age 5 years from the ACFBAL study and at ages 6-14 years for these subjects from the Australian Cystic Fibrosis Data Registry.Positive Aspergillus BAL cultures at age 5 years were significantly associated with increased HRCT scores for air trapping (OR 5.53, 95% CI 2.35 to 10.82). However, positive Aspergillus cultures were not associated with either FEV1% predicted at age 5 years or FEV1% predicted by age following adjustment for body mass index z-score and hospitalisation secondary to pulmonary exacerbations. Lung function demonstrated a non-linear decline in this population.In children with cystic fibrosis, positive Aspergillus BAL cultures at age 5 years were associated contemporaneously with air trapping but not bronchiectasis. However, no association was observed between positive Aspergillus BAL cultures on FEV1% predicted at age 5 years or with lung function decline between ages 5 years and 14 years.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
hhhh发布了新的文献求助10
刚刚
liu发布了新的文献求助10
1秒前
Dawn发布了新的文献求助20
1秒前
2秒前
袅袅完成签到 ,获得积分10
2秒前
3秒前
zebra发布了新的文献求助30
4秒前
张才豪发布了新的文献求助10
4秒前
IceyCNZ发布了新的文献求助20
4秒前
善学以致用应助我嘞个豆采纳,获得20
7秒前
mm发布了新的文献求助10
7秒前
小二郎应助啦啦啦采纳,获得10
7秒前
9秒前
SciGPT应助liu采纳,获得20
9秒前
幸福的冰珍完成签到,获得积分10
10秒前
10秒前
量子星尘发布了新的文献求助10
11秒前
pxh发布了新的文献求助10
11秒前
纯真又莲完成签到,获得积分10
13秒前
思源应助澡雪采纳,获得10
13秒前
混子完成签到,获得积分10
13秒前
可乐啊啊啊完成签到,获得积分10
13秒前
赘婿应助科研通管家采纳,获得10
14秒前
科目三应助科研通管家采纳,获得10
14秒前
上官若男应助科研通管家采纳,获得10
14秒前
干饭大王应助科研通管家采纳,获得10
14秒前
yx_cheng应助科研通管家采纳,获得20
15秒前
Captain_H应助科研通管家采纳,获得10
15秒前
李健应助科研通管家采纳,获得10
15秒前
领导范儿应助科研通管家采纳,获得10
15秒前
Ava应助科研通管家采纳,获得10
15秒前
15秒前
小二郎应助dhhaoyihong采纳,获得10
15秒前
fst发布了新的文献求助10
15秒前
16秒前
16秒前
乐乐宝完成签到,获得积分10
17秒前
wuji2077完成签到,获得积分10
18秒前
zcvxd发布了新的文献求助10
19秒前
mmmm发布了新的文献求助10
19秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975816
求助须知:如何正确求助?哪些是违规求助? 3520159
关于积分的说明 11201128
捐赠科研通 3256541
什么是DOI,文献DOI怎么找? 1798347
邀请新用户注册赠送积分活动 877539
科研通“疑难数据库(出版商)”最低求助积分说明 806426