类有机物
再生医学
干细胞
诱导多能干细胞
个性化医疗
药物发现
精密医学
药物开发
医学
生物
计算生物学
药品
神经科学
细胞生物学
药理学
生物信息学
病理
胚胎干细胞
遗传学
基因
出处
期刊:Annual Review of Pharmacology and Toxicology
[Annual Reviews]
日期:2019-01-06
卷期号:59 (1): 447-462
被引量:125
标识
DOI:10.1146/annurev-pharmtox-010818-021108
摘要
A wide variety of organs are in a dynamic state, continuously undergoing renewal as a result of constant growth and differentiation. Stem cells are required during these dynamic events for continuous tissue maintenance within the organs. In a steady state of production and loss of cells within these tissues, new cells are constantly formed by differentiation from stem cells. Today, organoids derived from either adult stem cells or pluripotent stem cells can be grown to resemble various organs. As they are similar to their original organs, organoids hold great promise for use in medical research and the development of new treatments. Furthermore, they have already been utilized in the clinic, enabling personalized medicine for inflammatory bowel disease. In this review, I provide an update on current organoid technology and summarize the application of organoids in basic research, disease modeling, drug development, personalized treatment, and regenerative medicine.
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