生物
缝隙连接
细胞内
细胞生物学
自噬
转录因子
基因
遗传学
细胞凋亡
作者
Tânia Martins‐Marques,Teresa Ribeiro‐Rodrigues,Daniela Batista-Almeida,Trond Aasen,Brenda R. Kwak,Henrique Girão
标识
DOI:10.1016/j.tcb.2019.07.001
摘要
Connexin43 (Cx43) is commonly associated with direct cell-cell communication through gap junctions (GJs). However, recent groundbreaking studies have challenged this dogma, implicating Cx43 in other biological processes, such as transcription, metabolism, autophagy, and ion channel trafficking. How Cx43 participates in these processes remains largely unknown, although its high turnover rate, capacity to bind to myriad proteins, and the discovery of truncated isoforms of Cx43, ascribe to this protein unanticipated roles in chief processes that require fine-tuned regulation. Accordingly, Cx43 can be regarded as a central integrative hub to which diverse cues converge to be processed in a concerted manner. In this review, we examine the noncanonical roles of Cx43 and discuss the implications of these functions in human diseases and future therapeutic strategies.
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