生物化学
消化(炼金术)
发酵
多糖
肠道菌群
脂质代谢
新陈代谢
化学
益生元
生物
食品科学
色谱法
作者
Jie Gao,Lianzhu Lin,Zijie Chen,Yongjian Cai,Chuqiao Xiao,Feibai Zhou,Baoguo Sun,Mouming Zhao
标识
DOI:10.1021/acs.jafc.9b00970
摘要
Our previous study has proved that the three polysaccharide fractions from L. japonica (LP-A4, LP-A6, and LP-A8) had significantly different structure characterization. Herein, we conducted in vitro simulated digestion and fermentation to study the digestive mechanism of LP-As. The results of gastrointestinal digestion indicated that LP-A6 and LP-A8 would be easier to trap the enzyme molecules for their denser interconnected macromolecule network compared with LP-A4. Fermentation of LP-As by human gut microbiota, especially for LP-A8, generated a large amount of short-chain fatty acids (SCFAs), which could upregulate the abundance of Firmicutes (Lachnoclostridium and Eubacterium). The high content of sulfate and highly branched sugar residue of LP-A8 might help it be easily used by Firmicutes in gut microbiota of hyperlipidemic patients. Functional analysis revealed that the increased metabolic activities of glycerophospholipid metabolism, ether lipid metabolism, and fatty acid metabolism induced by LP-A8 treatment were closely associated with metabolic syndromes and hyperlipidemia.
科研通智能强力驱动
Strongly Powered by AbleSci AI