声动力疗法
转铁蛋白受体
内吞作用
转铁蛋白
内化
细胞内
癌症研究
光敏剂
化学
细胞生物学
活性氧
受体
药理学
生物
生物化学
有机化学
作者
Liqun Zhang,Ning Wang,Ming Ma,Yu Luo,Hangrong Chen
标识
DOI:10.1002/adtp.201800152
摘要
Abstract Sonodynamic therapy overcomes the tissue penetration barrier of photo‐activated therapeutics, whereas the poor tumor penetration of sonosensitizers largely lowers therapeutic effectiveness. Here, a brand‐new strategy for achieving tumor deep penetration is developed by exploiting the cellular recycling transferrin (Tf). Specifically, a new type of nanosonosensitizer self‐assembled from Tf and organic sonosensitizer protoporphyrin IX is first designed, which exhibits expected biosafety, stability, and ultrasound‐activated cytotoxic reactive oxygen species (ROS) production capability ensuring in vivo administration. More importantly, the nanosonosensitizers inherit the unique transferrin receptor (TfR)‐mediated endocytosis and exocytosis behaviors of Tf, enabling specific binding to TfR‐overexpressed tumor cells and thereafter TfR‐mediated sequential intercellular delivery of nanosonosensitizers. Consequently, tumor deep delivery of sonosensitizers is achieved in TfR‐overexpressed HeLa tumors, which is considerably beneficial for desired tumor‐suppression effect with ROS‐mediated sonodynamic therapy protocol. Such a TfR‐mediated sequential intercellular relay strategy offers an innovative concept for the deep delivery of nanomedicines in tumors.
科研通智能强力驱动
Strongly Powered by AbleSci AI