生物利用度
脂质体
药代动力学
维生素
维生素C
化学
药理学
医学
生物化学
作者
Maciej Łukawski,Paulina Dałek,Tomasz Borowik,Aleksander Foryś,Marek Langner,Wojciech Witkiewicz,Magdalena Przybyło
标识
DOI:10.1080/08982104.2019.1630642
摘要
Vitamin C is the exogenous compound necessary for a variety of metabolic processes; therefore, the efficient delivery is critical for the maintenance of body homeostasis. Vitamin C pharmacokinetics and low quantities in processed foodstuff, necessitates its continuous supplementation. In the paper, we present the new liposomal formulation of vitamin C free of harmful organic solvents. The formulation was quantitatively characterized with respect to its chemically composition and nano-structuring. The vitamin C accessibility to cells from the formulation was evaluated using evidence derived from experiments performed on cell cultures. Finally, the enhanced bioavailability of vitamin C from the formulation was demonstrated in the medical experiment.
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