顺铂
精密医学
抗药性
化疗
医学
癌症医学
生物标志物
药品
癌症化疗
生物信息学
疾病
机制(生物学)
药理学
癌症
肿瘤科
内科学
生物
病理
遗传学
哲学
认识论
标识
DOI:10.1016/j.phrs.2016.01.001
摘要
Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of cancer types. Unfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. The use of precision medicine to make informed decisions on a patient's cisplatin resistance status and predicting the tumor response would allow the clinician to tailor the chemotherapy program based on the biology of the disease. In this review, key biomarkers of each molecular mechanism will be discussed along with the current clinical research. Additionally, known polymorphisms for each biomarker will be discussed in relation to their influence on cisplatin resistance.
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