嘌呤能受体
嘌呤能信号
伤害
神经病理性疼痛
同色
神经科学
受体
医学
P2Y12
药理学
化学
腺苷受体
生物
内科学
兴奋剂
生物化学
基因
蛋白质亚单位
血小板
血小板聚集
出处
期刊:Advances in pharmacology
日期:2015-11-05
卷期号:: 91-137
被引量:154
标识
DOI:10.1016/bs.apha.2015.09.001
摘要
There is a brief introductory summary of purinergic signaling involving ATP storage, release, and ectoenzymatic breakdown, and the current classification of receptor subtypes for purines and pyrimidines. The review then describes purinergic mechanosensory transduction involved in visceral, cutaneous, and musculoskeletal nociception and on the roles played by receptor subtypes in neuropathic and inflammatory pain. Multiple purinoceptor subtypes are involved in pain pathways both as an initiator and modulator. Activation of homomeric P2X3 receptors contributes to acute nociception and activation of heteromeric P2X2/3 receptors appears to modulate longer-lasting nociceptive sensitivity associated with nerve injury or chronic inflammation. In neuropathic pain activation of P2X4, P2X7, and P2Y12 receptors on microglia may serve to maintain nociceptive sensitivity through complex neural-glial cell interactions and antagonists to these receptors reduce neuropathic pain. Potential therapeutic approaches involving purinergic mechanisms will be discussed.
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