Anti-parasitic effects of Leptomycin B isolated from Streptomyces sp. CJK17 on marine fish ciliate Cryptocaryon irritans

生物 纤毛的 海鱼 微生物学 动物 渔业 生态学
作者
Fei Yin,Peng Sun,Baojun Tang,Hui Gong,Qiaozhen Ke,An‐Xing Li
出处
期刊:Veterinary Parasitology [Elsevier BV]
卷期号:217: 89-94 被引量:18
标识
DOI:10.1016/j.vetpar.2015.12.034
摘要

The present study was conducted aiming to evaluate the in vitro and in vivo anti-parasitic efficacy of an isolated compound against the ciliate Cryptocaryon irritans. The compound was previously isolated from fermentation products of Streptomyces sp. CJK17 and designated as SFrD. Toxicity of the compound SFrD against the fish hosts (Larimichthys crocea) was also tested and its chemical structure was elucidated. The obtained results showed that the compound has potent anti-parasitic efficacy with the 10 min-, 1 h-, 2 h-, 3 h- and 4 h-LC50 (95% Confidence Intervals) of 6.8 (6.5–7.1), 3.9 (2.8–5.0), 3.3 (2.6–4.0), 2.7 (2.3–3.1) and 2.5 (2.2–2.8) mg L−1 against theronts of C. irritans and the 6 h-LC50 (95% CI) of 3.0 (2.8–3.2) mg L−1 against the tomonts, respectively. Exposure of the compound SFrD remarkably reduced the mortality of fish infected with C. Irritans, from 100% in the control group to 61.7% and 38.3% in groups of 3.1 mg L−1 and 6.3 mg L−1, respectively. In the test of exposing fish to 40 mg L−1 compound SFrD for 24 h, no visible effects were observed affecting the normal behavior or any macroscopic changes. By spectrum analysis (EI-MS, 1H NMR and 13C NMR), the compound SFrD was identified as Leptomycin B. This study firstly demonstrated that Leptomycin B has potent anti-parasitic efficacy against ciliates in cultured marine fish.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xdm完成签到,获得积分10
1秒前
hero发布了新的文献求助10
3秒前
4秒前
mengjianfen发布了新的文献求助10
4秒前
汉堡包应助tsunami采纳,获得10
4秒前
4秒前
甜甜的剑愁完成签到,获得积分10
6秒前
Starwalker应助houfei采纳,获得10
8秒前
djiwisksk66应助houfei采纳,获得10
8秒前
zzz完成签到,获得积分20
8秒前
8秒前
hero完成签到,获得积分10
8秒前
慧休休发布了新的文献求助10
8秒前
王德霞发布了新的文献求助10
9秒前
所所应助超的爱123采纳,获得10
10秒前
范美娇发布了新的文献求助10
11秒前
NING完成签到 ,获得积分10
12秒前
风倾蓝白发布了新的文献求助10
13秒前
量子星尘发布了新的文献求助10
17秒前
17秒前
19秒前
大土豆子完成签到,获得积分10
19秒前
搜集达人应助风倾蓝白采纳,获得10
22秒前
25秒前
ly完成签到,获得积分10
25秒前
29秒前
宁ning完成签到 ,获得积分10
32秒前
乌苏完成签到 ,获得积分10
33秒前
JWW完成签到,获得积分10
34秒前
34秒前
zhiyao2025完成签到,获得积分10
35秒前
xiazhq完成签到,获得积分10
36秒前
零零灵完成签到,获得积分10
37秒前
zhangruiii发布了新的文献求助10
39秒前
lemon完成签到,获得积分10
40秒前
安安安安完成签到,获得积分10
40秒前
番茄完成签到,获得积分10
40秒前
41秒前
ZZ发布了新的文献求助30
42秒前
幽默的凡完成签到 ,获得积分10
42秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971441
求助须知:如何正确求助?哪些是违规求助? 3516161
关于积分的说明 11181180
捐赠科研通 3251322
什么是DOI,文献DOI怎么找? 1795788
邀请新用户注册赠送积分活动 876026
科研通“疑难数据库(出版商)”最低求助积分说明 805228