Anti-parasitic effects of Leptomycin B isolated from Streptomyces sp. CJK17 on marine fish ciliate Cryptocaryon irritans

生物 纤毛的 海鱼 微生物学 动物 渔业 生态学
作者
Fei Yin,Peng Sun,Baojun Tang,Hui Gong,Qiaozhen Ke,An‐Xing Li
出处
期刊:Veterinary Parasitology [Elsevier BV]
卷期号:217: 89-94 被引量:18
标识
DOI:10.1016/j.vetpar.2015.12.034
摘要

The present study was conducted aiming to evaluate the in vitro and in vivo anti-parasitic efficacy of an isolated compound against the ciliate Cryptocaryon irritans. The compound was previously isolated from fermentation products of Streptomyces sp. CJK17 and designated as SFrD. Toxicity of the compound SFrD against the fish hosts (Larimichthys crocea) was also tested and its chemical structure was elucidated. The obtained results showed that the compound has potent anti-parasitic efficacy with the 10 min-, 1 h-, 2 h-, 3 h- and 4 h-LC50 (95% Confidence Intervals) of 6.8 (6.5–7.1), 3.9 (2.8–5.0), 3.3 (2.6–4.0), 2.7 (2.3–3.1) and 2.5 (2.2–2.8) mg L−1 against theronts of C. irritans and the 6 h-LC50 (95% CI) of 3.0 (2.8–3.2) mg L−1 against the tomonts, respectively. Exposure of the compound SFrD remarkably reduced the mortality of fish infected with C. Irritans, from 100% in the control group to 61.7% and 38.3% in groups of 3.1 mg L−1 and 6.3 mg L−1, respectively. In the test of exposing fish to 40 mg L−1 compound SFrD for 24 h, no visible effects were observed affecting the normal behavior or any macroscopic changes. By spectrum analysis (EI-MS, 1H NMR and 13C NMR), the compound SFrD was identified as Leptomycin B. This study firstly demonstrated that Leptomycin B has potent anti-parasitic efficacy against ciliates in cultured marine fish.
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