核酸
生物正交化学
核糖核酸
模板
化学生物学
生物化学
细胞内
小分子
DNA
化学
生物
组合化学
体内分布
计算生物学
纳米技术
点击化学
基因
材料科学
体外
作者
Margherita Di Pisa,Oliver Seitz
出处
期刊:ChemMedChem
[Wiley]
日期:2017-06-21
卷期号:12 (12): 872-882
被引量:51
标识
DOI:10.1002/cmdc.201700266
摘要
Abstract Nucleic acid directed bioorthogonal reactions offer the fascinating opportunity to unveil and redirect a plethora of intracellular mechanisms. Nano‐ to picomolar amounts of specific RNA molecules serve as templates and catalyze the selective formation of molecules that 1) exert biological effects, or 2) provide measurable signals for RNA detection. Turnover of reactants on the template is a valuable asset when concentrations of RNA templates are low. The idea is to use RNA‐templated reactions to fully control the biodistribution of drugs and to push the detection limits of DNA or RNA analytes to extraordinary sensitivities. Herein we review recent and instructive examples of conditional synthesis or release of compounds for in cellulo protein interference and intracellular nucleic acid imaging.
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