阿魏酸
化学
代谢物
体内
离体
血压
咖啡因
内分泌学
药理学
内科学
生物化学
生物
医学
体外
生物技术
作者
Evelien Van Rymenant,John Van Camp,Bart Pauwels,Charlotte Boydens,Laura Vanden Daele,Katrijn Beerens,Peter Brouckaert,Guy Smagghe,Asimina Kerimi,Gary Williamson,Charlotte Grootaert,Johan Van de Voorde
标识
DOI:10.1016/j.jnutbio.2017.02.018
摘要
Consumption of foods rich in ferulic acid (FA) such as wholegrain cereals, or FA precursors such as chlorogenic acids in coffee, is inversely correlated with risk of cardiovascular disease and type 2 diabetes. As a result of digestion and phase II metabolism in the gut and liver, FA is converted predominantly into ferulic acid-4-O-sulfate (FA-sul), an abundant plasma metabolite. Although FA-sul is the main metabolite, very little has been reported regarding its bioactivities. We have compared the ex vivo vasorelaxing effect of FA and FA-sul (10-7-3.10-5M) on isolated mouse arteries mounted in tissue myographs. FA-sul, but not FA, elicited a concentration-dependent vasorelaxation of saphenous and femoral arteries and aortae. The FA-sul-mediated vasorelaxation was blunted by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, a soluble guanylate cyclase (sGC) inhibitor. The role of sGC was confirmed in femoral arteries isolated from sGCα1(-/-) knockout mice. Furthermore, 4-aminopyridine, a specific inhibitor of voltage-dependent potassium channels, significantly decreased FA-sul-mediated effects. In anesthetized mice, intravenous injection of FA-sul decreased mean arterial pressure, whereas FA had no effect, confirming the results obtained ex vivo. FA-sul is probably one of the major metabolites accounting for the blood pressure-lowering effects associated with FA consumption.
科研通智能强力驱动
Strongly Powered by AbleSci AI