A Catalytic, One-pot and Green Synthesis of α-Amino Nitriles: Cu(BF4)2.x H2O an Efficient Catalyst

Background: The Strecker reaction is a first reported multicomponent reaction for the preparation of a-aminonitriles. The a-aminonitriles are important intermediates for various aminoacids, 1,2-diazines, heterocycles and biologically active compounds like Saframycin A and Ecteinascidin 746. The preparation of a-aminonitriles by Strecker approach using MCR attracted many research groups owing atom economy to avoid multistep synthesis and to follow Green chemistry principles. Keywords: α-Amino nitriles, copper(II)tetrafluoroborate, green chemistry, one-pot synthesis, solvent free, Strecker synthesis.