Sodium Iodide/Hydrogen Peroxide‐Mediated Oxidation/Lactonization for the Construction of Spirocyclic Oxindole‐Lactones

Abstract The sodium iodide/hydrogen peroxide‐mediated oxidation/lactonization of indolepropionic acids was achieved, affording the corresponding spirocyclic oxindole‐lactones in moderate to high yields. This metal‐free procedure features mild reaction conditions, non‐toxicity and easy handling, with hydrogen peroxide (H 2 O 2 ) as a clean oxidant. magnified image