切碎
未折叠蛋白反应
HMOX1型
分子生物学
基因表达
细胞培养
内质网
单元格排序
地塞米松
生物
化学
基因
癌症研究
内分泌学
细胞生物学
生物化学
遗传学
酶
流式细胞术
血红素
血红素加氧酶
作者
Aynur Duzgun,Abdulkerim Bedir,Tülay Özdemir,Rukiye Nar,Veli Kilinc,Osman Salis,Hasan Alacam,Sedat GÜLTEN
出处
期刊:PubMed
日期:2013-12-01
卷期号:50 (6): 505-10
被引量:4
摘要
The endoplasmic reticulum (ER) is related to the various signal routes that are activated in unfolded protein response (UPR). The Grp78, Grp94, CHOP, MTJ1 and HMOX1 genes expressions demonstrate UPR activity. In this study, we investigated the UPR gene expressions in larynx epidermoid carcinoma (HEp2) to which dexamethasone (dex) was applied. HEp2 cells were administered for 48 h with different combinations using 0.1 microM and 1 microM dex, 1 mM phenyl butyric acid (PBA) and 100 ng/ml lipopolysaccharide (LPS). The Grp78, Grp94, CHOP, MTJ1 and HMOX1 genes expression was determined using quantitative RT-PCR. The Grp78, MTJ1 and HMOX1 gene expression increased with the administration of 1 microM dex. CHOP expression, on the other hand, decreased with 0.1 microM dex. When dex was combined with LPS, nearly all gene expressions decreased. The increase in Grp78, Grp94, HMOX1 and MTJ1 gene expression was greater in groups in which dex was administered in combination with PBA than in groups in which dex was administered alone. Dex in low dose (0.1 microM) caused a decrease in CHOP expression in HEp2 cells and an increase in Grp78 expression, in particular. The changes in UPR genes expressions may lead to the extended survival of the cells.
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